Cellular signaling

Academician Vanyo Mitev's book "Cell Signaling" is a luxurious color edition with hard covers, 619 pages. Large format, including 210 figures, 172 boxes and 32 tables.

"With this textbook, I fulfilled an old duty of mine to medical students and the medical scientific community. This work will benefit students, doctoral students. Lecturers and researchers in medicine, dentistry, pharmacy, biochemistry; molecular and cellular biology, as well as to all medical professionals.

Regardless of their professional direction, having scientific interests, as well as the desire to be up-to-date on the modern understanding of the pathogenesis and modern treatment of diseases. I wrote it for two years, from 2 to 8 hours every day, and I had been preparing for it since 1984. When I entered with my post-graduate studies in biochemistry in the field of cell signaling", Academician Vanyo Mitev told about the new edition.

The textbook can be conditionally divided into 3 sections: chapters 2-7 are devoted to the consideration of fundamental concepts; such as post-translational modifications, receptors.

G-proteins, transcription factors, growth factors; cellular oncogenes and tumor suppressor genes, types of protein-protein interactions, etc., without which understanding the mechanisms of transduction pathways will be impossible.

Following is the description of 17 transduction pathways (PKA, PKC, MAPK, CaMK, JAK/STAT, PKB/Akt, mTOR, Wnt, NFkB, Hedgehog, TGFb, RET, Notch, Reelin;Hippo, Merlin and CK2) and finally 3 chapters, dedicated to cell death, oncogenesis and Covid-19.

Prof. Dr. Vladimir Neychev, Orlando University, Florida, USA:

This is an extremely complex and difficult work to write, requiring high competence and great working ability. It's amazing that there is only one author! There is no similar analogue in the world literature and there is already interest in its English version. The book is an invaluable aid for clinicians of all specialties.

Art. Cor. Rumen Pankov, BF of SU:

A book has finally appeared that dares to present Cell Signaling in its entirety, describing all the known signaling cascades used by the cell to communicate. In the book, a huge amount of information is professionally summarized (abbreviations alone are nearly 900), which is within the capabilities of only a specialist like Academician Mitev.

For more than 35 years, he has taught and conducted research in this rapidly developing field of biomedical science, rightly called the "Crest of Science." I do not know of a similar work (not only in Bulgaria) dedicated to Cellular signaling with such a structure and comprehensiveness, and I believe that its translation into English is mandatory.

Prof. Dr. Tsvetelina Tankova, deputy. Rector of MU-Sofia - head of the Department of Endocrinology:

Cell signaling processes are the basis of hormone action mechanisms, and the overall diagnostic and therapeutic approach is based on them. The book is a challenge, a valuable aid that will enrich the knowledge of clinicians about the pathogenesis and the latest therapeutic methods of cancer, neurodegenerative, metabolic and many other diseases and rare syndromes.

• Cellular
• signaling

Cell Signaling is a comprehensive medical textbook on the molecular mechanisms and processes that regulate communication between cells. The authors of the textbook are experts in the field of cell biology and molecular medicine, which gives this source authority and relevance.

The textbook introduces readers to the fundamental concepts of cell signaling in a comparative and systematic manner. Key aspects such as receptors, second messengers, signaling pathways and regulatory molecules are included. This basic block of information is essential for understanding the more complex aspects of cell signaling.

Special attention is paid to the diverse types of receptors that play a key role in signal transduction. From membrane-bound surface receptors to intracellular receptors, the authors analyze how different receptors recognize signals and activate relevant pathways in the cellular environment.

The textbook also provides detailed information on the various classes of signaling pathways, including the G protein, tyrosine kinase, and inositol triphosphate pathways. The authors explain what happens in the cell after the activation of these pathways and how they regulate various biological processes.

An important aspect of the textbook is the emphasis on the role of cell signaling in physiology and pathology. Mechanisms that govern cell differentiation, growth, survival, and death are discussed. The authors also analyze how abnormalities in cell signaling can contribute to a variety of diseases, including cancer, infections and neurodegenerative conditions.

Interactive elements such as illustrations, graphics, and clinical applications enrich the textbook and make complex concepts easier to understand. They also provide students and healthcare professionals with the opportunity to connect theoretical knowledge with practical aspects of cell signaling.

Current trends and new advances in cell signaling are also presented in the textbook. This includes information on new technologies for studying signaling pathways as well as potential therapeutic options based on knowledge in this field.

In conclusion, Cell Signaling is a comprehensive and comprehensive source of knowledge in the fields of cell biology and medicine. This textbook not only provides a theoretical basis for understanding cell signaling, but also relates this knowledge to clinical reality, making it a valuable resource for educational and research purposes.