This volume discusses the latest advances in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive, Liver Carcinogenesis: Methods and Protocols, is a valuable resource for students and scientists who are interested in driving progress in the important field of liver cancer research.
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Liver Carcinogenesis is a comprehensive and up-to-date guide to the mechanisms of liver cancer formation. The authors, Edward Levine, MD, PhD, and Michael Levine, MD, PhD, provide a comprehensive review of the factors involved in the development of hepatocellular carcinoma (HCC), including genetic, epigenetic, and environmental factors.
The textbook begins with an introduction to liver oncogenesis, which provides an overview of the study of liver cancer formation. He then moves on to the basic principles of hepatocellular biology, including the role of the liver stem cells and liver development.
Subsequent sections of the textbook focus on the specific factors that contribute to hepatocellular carcinoma, discussing their roles in the initiation, progression, and progression of the disease. In each chapter, the authors discuss relevant genetic changes, epigenetic modifications, and environmental factors, such as alcohol, hepatitis viruses, and chemical carcinogens, and how they contribute to the development of HCC. This information is presented in an easy-to-understand manner, making it easier for clinicians and researchers to gain a comprehensive understanding of the complex mechanisms that lead to hepatocellular carcinoma.
One of the notable qualities of Liver Carcinogenesis is its emphasis on a multidisciplinary approach to the study of hepatocellular carcinoma. The authors integrate knowledge from various fields, including genetics, epigenetics, immunology and toxicology to provide a comprehensive overview of hepatocellular oncogenesis.
Additional features included in this textbook further enhance its usefulness. These features include:
- Case studies: The textbook presents numerous real cases from clinical practice that illustrate the practical application of knowledge of hepatocellular oncogenesis. These case studies serve as valuable tools to stimulate critical thinking and encourage discussions about treatment choices and prognosis for patients with hepatocellular carcinoma.
- Online Resources: Along with the print edition, an online study kit is available that includes interactive exercises, self-assessment tests and additional information on selected topics. These digital resources complement the book's content and provide clinicians and researchers with a convenient way to review and apply their knowledge.
- Glossary: The textbook includes a comprehensive glossary that defines key terms used throughout the text. This reference helps clinicians and researchers quickly look up and understand unfamiliar terms while reading.
Overall, Liver Carcinogenesis is a comprehensive and well-organized guide to hepatocellular oncogenesis. Its combination of solid scientific material, clinical applications, and diverse features make it an indispensable tool for both clinicians dealing with liver disease and researchers who want to improve our understanding of liver cancer formation and develop new strategies for its prevention. and treatment. Whether used as a primary textbook or a reference, this textbook will undoubtedly contribute to a deeper understanding of the world of hepatocellular oncogenesis and its applications in modern medicine.
