This issue of Interventional Cardiology Clinics, edited by Dr. Marvin H. Eng, will focus on Transcatheter aortic valve replacement. Topics discussed in this issue include, but are not limited to: Choosing between transcatheter heart valves and surgery in a world with low-risk TAVR, Femoral access, hemostasis and vascular complications for TAVR, Balloon expandable Edwards Sapien Transcatheter Heart Valves: Safety and Efficacy , Conduction Delay and Pacing in TAVR, Mechanical complications of TAVR, Risk and mitigation of coronary obstruction in TAVR, Valve-in-Valve TAVR, Alternative Access for TAVR, Neurological complications in TAVR, Early leaflet thickening, durability and bioprosthetic valve failure in TAVR , Treatment of Bicuspid aortic valve stenosis using transcatheter heart valves, Revascularization in the TAVR population and New Bioprosthetic valve technologies.