The present edition of Xenobiotics consists of four sections:
fundamentals of toxicology,
toxic substances,
morphology of damage with toxic substances and drugs,
cell-protective and therapeutic strategies, and covers 47 topics.
It is aimed at the needs of specialists working in the field of pharmaceutical sciences, and is built on the modern training programs for master pharmacists. The book describes the basic knowledge about toxicological profile of chemical substances and preparations. An important place is occupied by the understanding of the cellular-molecular mechanisms of cytotoxicity. The concept of bioactivation on xenobiotics.
The chemical nature, physical properties, and toxic effects of substances are described, and some modern guidelines for determining the relationship between chemical structure and toxicity are presented. An assessment of the pharmacological safety profile of some groups of drugs and the possible remote risk of genotoxicity, carcinogenesis or other type of chemical exposure damage.
The principles and specific treatment of intoxications with antidote drugs. The possibilities of cell protection with antioxidants, membrane-therapeutic and other agents that favorably affect cell function.
The European requirements and norms for the control of harmful substances from the environment are reflected.
This edition represents an integrated knowledge of the toxicity of chemical substances and the safety profile of medicines obtained as an achievement of toxicology, biology, chemistry, ecochemistry and ecometrics, pharmacology and metabonomics, as well as in the field of prevention for the protection of human health. It is intended for students and specialists in pharmacy, but is also of interest to specialists working in the medical field toxicochemistry and ecochemistry, as well as for the regulatory institutions for the control of drugs or environmental hazards.
Prof. Dr. M. Karaivanova, MD
