Genomic Medicine, Part 2
I. Fundamentals of Human Genetics
1. Place of genetics and genomics in medicine
2. The organization of nuclear DNA in humans
3. Population genetics. Variability and evolution of the gene pool
4. Microscopic and submicroscopic structure and function of chromosomes
5. Proteomics in medicine
II. Etiology and diagnosis of hereditary diseases
6. Etiology of hereditary diseases
7. Diagnosis of genetic diseases
III. Clinical genetics
8. Monogenic diseases
9. Hereditary diseases with dynamic mutations
10. Mitochondrial diseases
11. Chromosomal diseases
12. Syndrome with defects of adjacent genes - microdeletion and microduplication syndromes
IV. Genomic medicine - genetic predisposition to common diseases
13. General characteristics of multifactorial diseases
14. Genetic epidemiology. family, twin and adoption studies
15. Genetic polymorphism
16. Genetic predisposition to cardiovascular diseases
17. Genetic predisposition to gastrointestinal diseases
18. Genetic factors in endocrine diseases
19. Genetics of some psychiatric diseases
20. Genetic predisposition to lung diseases
21. Genetic determination of overweight
22. Genetics of cancer. Common feature
23. Genetics of hereditary cancers
24. Dysmorphology and teratogenesis
25. Retardation in mental development
26. Genetics of autism spectrum disorders
27. Genetic causes of infertility
V. Preventive medicine
28. Preimplantation genetics diagnosis (PGD) and Screening (PGS)
29. Prenatal diagnosis of monogenic and chromosomal diseases
30. Screening programs
31. Medical-genetic consultation
32. moral-ethical, psychological and legal aspects of genetic prevention
VI. Personalized medicine
33. Essence of personalized genomic medicine
34. Pharmacogenetics
35. pharmacogenomics
36. Era of targeted therapy
